{"id":22321,"date":"2025-03-06T08:00:00","date_gmt":"2025-03-06T14:00:00","guid":{"rendered":"https:\/\/naturalwomanhood.org\/?p=22321"},"modified":"2025-05-06T11:19:24","modified_gmt":"2025-05-06T16:19:24","slug":"n-%d0%b0%d1%86%d0%b5%d1%82%d0%b8%d0%bb%d1%86%d0%b8%d1%81%d1%82%d0%b5%d0%b8%d0%bd-%d1%8d%d0%bd%d0%b4%d0%be%d0%bc%d0%b5%d1%82%d1%80%d0%b8%d0%be%d0%b7","status":"publish","type":"post","link":"https:\/\/naturalwomanhood.org\/ru\/n-acetylcysteine-endometriosis\/","title":{"rendered":"N-\u0430\u0446\u0435\u0442\u0438\u043b\u0446\u0438\u0441\u0442\u0435\u0438\u043d (NAC): \u041c\u043e\u0436\u0435\u0442 \u043b\u0438 \u0431\u0435\u0437\u0440\u0435\u0446\u0435\u043f\u0442\u0443\u0440\u043d\u0430\u044f \u0434\u043e\u0431\u0430\u0432\u043a\u0430 \u043f\u043e\u043c\u043e\u0447\u044c \u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u044d\u043d\u0434\u043e\u043c\u0435\u0442\u0440\u0438\u043e\u0437\u0430?"},"content":{"rendered":"\n

Endometriosis is a common female hormonal disorder characterized by estrogen dominance and endometrial-like tissue<\/a> growing outside <\/em>the uterus. (Recall that the endometrium<\/a> is the lining of the uterus or womb.) Endometriosis is estimated<\/a> to affect between 2-10% of women and at least 50% <\/em>of women who struggle with infertility [1]. It is an inflammatory<\/a> condition that often manifests in debilitating pelvic pain, heavy periods, abnormal bleeding, and infertility [2]. On the other hand, endo can also be hidden, showing few or no symptoms, which can make it difficult to diagnose.\u00a0\u00a0<\/p>\n\n\n\n

Currently, the \u201cgold-standard\u201d treatment for endometriosis is laparoscopic surgery to remove endometrial lesions. Unfortunately, this surgery<\/a> can be expensive and does not guarantee that endometrial lesions won\u2019t regrow in the future. Another common form of treatment is hormonal birth control, which suppresses symptoms but does not cure endometriosis. Additionally, this treatment can have harmful side effects.\u00a0<\/p>\n\n\n\n

Because of these less-than-ideal treatment methods, some researchers are seeking better treatment alternatives for endometriosis. One promising treatment for endo may be supplementation with N-acetylcysteine, known as NAC. <\/p>\n\n\n\n

What is N-acetylcysteine?<\/span><\/h2>\n\n\n\n

NAC is a supplement form<\/a> of the amino acid L-cysteine. It has an anti-inflammatory<\/a> and antioxidant effect on the body, making it an effective treatment<\/a> for acetaminophen (Tylenol) overdose [1][3]. It also has the potential to treat cancer, lung disease, insulin resistance, blood clotting, and, as we are going to look at today, fertility diseases like endometriosis [3].\u00a0<\/p>\n\n\n\n

What did we already know about N-acetylcysteine\u2019s effects on endometriosis?<\/span><\/h2>\n\n\n\n

A previous study<\/a> from 2013 observed women with confirmed ovarian endometrial lesions who were or were not treated with NAC over a 3-month period [2]. Those treated with NAC experienced a significant number of decreased or disappearing lesions. Fewer women in the NAC treatment group experienced enlarged or new cysts compared to untreated women. The NAC treatment group also reported lessened pelvic pain.\u00a0<\/p>\n\n\n\n

A newer study shed more light on whether NAC could help women with endometriosis<\/span><\/h2>\n\n\n\n

From January 2020 to April 2022, 120 women aged 18-45 years old who had been diagnosed with endometriosis and were being treated through the endometriosis outpatient service of\u00a0 Policlinico Umberto I-Sapienza University Hospital (in Rome, Italy), participated in a study<\/a>. The researchers\u2019 goal was to further demonstrate the positive effects NAC supplementation has on endometriosis. They also wanted to evaluate whether NAC could positively affect fertility.<\/p>\n\n\n\n

All of the patients were treated with 600 mg of oral NAC supplementation, 3 days a week for 3 months. The patients were assessed for endometriosis symptom severity before and after treatment. Their endometrial lesions were also measured through ultrasound before and after treatment. Researchers also assessed pregnancy rates in a subgroup of women who sought to conceive. <\/p>\n\n\n\n

N-acetylcysteine supplementation reduced pain and endometrial lesion size<\/span><\/h2>\n\n\n\n

The Italian study concluded that oral NAC supplementation is a viable method of treating both endometriosis pain and the size of ovarian endometriomas. Throughout the treatment, the intensity of endometriosis symptoms, including painful periods, significantly improved. Ovarian endometriomas (endometrial lesions on the ovaries) present before<\/em> treatments demonstrated significant size reduction at the end of the three months. <\/p>\n\n\n\n

Strikingly, 75% of the subgroup of women treated with NAC who desired to conceive (that is, 39 out of 52) achieved pregnancy without reproductive treatments within 6 months of beginning NAC supplementation. <\/p>\n\n\n\n

Strikingly, 75% of the subgroup of women treated with NAC who desired to conceive (that is, 39 out of 52) achieved pregnancy without reproductive treatments within 6 months of beginning NAC supplementation.\u00a0<\/p><\/blockquote><\/figure>\n\n\n\n

An additional observation was a decrease in BMI for many of the participants. <\/p>\n\n\n\n

N-acetylcysteine appears to be safe, affordable, and effective<\/span><\/h2>\n\n\n\n

The researchers also noted that no negative side effects were discovered, suggesting that NAC is a safe, affordable, and effective form of endometriosis treatment. Because the goal of this study was to confirm the findings of past research, the researchers noted the findings as conclusive. Still, studies with much larger sample sizes than 120 participants are necessary to truly confirm NAC\u2019s benefits for women with endometriosis.  <\/p>\n\n\n\n

Should you supplement with NAC?<\/span><\/h2>\n\n\n\n

NAC supplements can be bought over the counter. As with any supplement, before you get started, discuss NAC supplementation with your doctor or other healthcare professional to ensure it does not interact with any of your current medications or health conditions. Also, you may first want to try increasing high-protein foods in your diet like beef, chicken, eggs, and whole grains. These foods are natural sources of cysteine, which NAC is the supplement for. <\/p>\n\n\n\n

If your provider recommends NAC supplementation, the typical recommendation ranges are between 600 to 1,800 mg daily. It is worth noting that the participants<\/a> of the 2023 study only took 600 mg three times a week, so NAC may not need to be a daily supplement for a woman to see benefits [1]. This is another reason to discuss N-acetylcysteine supplementation with your healthcare professional.\u00a0<\/p>\n\n\n\n

The bottom line on N-acetylcysteine for endometriosis<\/span><\/h2>\n\n\n\n

Certainly, N-acetylcysteine supplementation alone may be insufficient to adequately treat endometriosis. But given how safe, inexpensive, and easy to access it is, it may be a great place to start or something to try alongside other endometriosis treatments. And since infertility co-exists with endometriosis for many, many women, N-acetylcysteine\u2019s potential benefits on fertility may be an added bonus.  <\/p>\n\n\n\n

References:<\/span><\/h4>\n\n\n\n[1] Anastasi E, Scaramuzzino S, Viscardi MF, et al. Efficacy of N-Acetylcysteine on Endometriosis-Related Pain, Size Reduction of Ovarian Endometriomas, and Fertility Outcomes. Int J Environ Res Public Health. 2023 Mar 7;20(6):4686. doi: 10.3390\/ijerph20064686. PMID: 36981595; PMCID: PMC10048621.<\/p>\n\n\n\n[2] Porpora MG, Brunelli R, Costa G, et al. A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine. Evid Based Complement Alternat Med. 2013;2013:240702. doi: 10.1155\/2013\/240702. Epub 2013 May 7. PMID: 23737821; PMCID: PMC3662115.<\/p>\n\n\n\n[3] Ten\u00f3rio MCDS, Graciliano NG, Moura FA, et al. N<\/em>-Acetylcysteine (NAC): Impacts on Human Health. Antioxidants (Basel). 2021 Jun 16;10(6):967. doi: 10.3390\/antiox10060967. PMID: 34208683; PMCID: PMC8234027.<\/p>\n","protected":false},"excerpt":{"rendered":"\u0427\u0442\u043e \u043f\u043e\u043a\u0430\u0437\u044b\u0432\u0430\u044e\u0442 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f","protected":false},"author":110,"featured_media":22323,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","csco_singular_sidebar":"","csco_page_header_type":"","csco_page_load_nextpost":"","csco_post_video_location":[],"csco_post_video_url":"","csco_post_video_bg_start_time":0,"csco_post_video_bg_end_time":0,"footnotes":""},"categories":[5364,5181],"tags":[4719,6441,5807],"class_list":{"0":"post-22321","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-endometriosis","8":"category-reproductive-and-menstrual-disorders","9":"tag-endometriosis","10":"tag-endometriosis-medication","11":"tag-endometriosis-pain","12":"cs-entry","13":"cs-video-wrap"},"acf":[],"yoast_head":"\nN-acetylcysteine (NAC) for endometriosis- NW<\/title>\n<meta name=\"description\" content=\"Could over-the-counter supplement N-acetylcysteine (NAC) help treat endometriosis? 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