{"id":23572,"date":"2025-10-09T08:00:39","date_gmt":"2025-10-09T13:00:39","guid":{"rendered":"https:\/\/naturalwomanhood.org\/?p=23572"},"modified":"2025-10-10T09:54:55","modified_gmt":"2025-10-10T14:54:55","slug":"tylenol-pendant-la-grossesse-liens-sur-lautisme-et-le-trouble-deficitaire-de-lattention","status":"publish","type":"post","link":"https:\/\/naturalwomanhood.org\/fr\/tylenol-in-pregnancy-autism-adhd-links\/","title":{"rendered":"Le Tylenol pendant la grossesse : Ce que l'\u00e9tude Mt. Sinai\/Harvard nous apprend sur les liens avec l'autisme et d'autres troubles du d\u00e9veloppement neurologique"},"content":{"rendered":"\n<p>You\u2019re 22 weeks pregnant. A migraine blooms behind your right eye, and Tylenol sits in your medicine cabinet. Your OB has always said it\u2019s safe, but a few weeks ago, headlines linked it to autism and ADHD. Suddenly, a once-simple decision feels loaded.<\/p>\n\n\n\n<p>For decades, acetaminophen (the generic name for Tylenol in the United States\u2013more commonly known as paracetamol in the rest of the world) has been considered the go-to pain reliever in pregnancy. Doctors have long advised against ibuprofen, aspirin, and stronger drugs, leaving expectant mothers with few choices for pain relief. Tylenol was framed as the safest bet. But recent research, culminating in <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40804730\/\" target=\"_blank\" rel=\"noreferrer noopener\">a study published in August 2025 in the journal <em>BMC Environmental Health<\/em><\/a><em>, <\/em>is now reshaping the narrative [1].&nbsp;<\/p>\n\n\n\n<p>Titled \u201cEvaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology,\u201d this joint systematic review of literature was led by a team of researchers from the Icahn School of Medicine at Mount Sinai and Harvard T.H. Chan School of Public Health. And, after its publication, the weight of evidence was deemed strong enough that the <a href=\"https:\/\/www.hhs.gov\/press-room\/hhs-trump-kennedy-autism-initiatives-leucovorin-tylenol-research-2025.html\" target=\"_blank\" rel=\"noreferrer noopener\">U.S. Secretary of Health and Human Services began urging caution<\/a> with acetaminophen use in pregnancy.<\/p>\n\n\n\n<p>So what\u2019s actually new here? And how should women make sense of it?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-a-decade-of-mounting-concerns\"><span id=\"a-decade-of-mounting-concerns\">A decade of mounting concerns<\/span><\/h2>\n\n\n\n<p>Concerns about Tylenol in pregnancy (and <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK441917\/#:~:text=Although%20relatively%20safe%20at%20therapeutic,failure%20in%20the%20United%20States.\" target=\"_blank\" rel=\"noreferrer noopener\">outside of it<\/a>) aren\u2019t new.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24566677\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>2014 Danish cohort study<\/strong> <strong>in <em>JAMA Pediatrics<\/em><\/strong><\/a><strong>:<\/strong> Suggested an association between prenatal acetaminophen exposure and ADHD in children. It was observational, meaning it couldn\u2019t prove causation, but it raised eyebrows [2].<\/li>\n\n\n\n<li><a href=\"https:\/\/academic.oup.com\/aje\/article-abstract\/187\/8\/1817\/4980325?redirectedFrom=fulltext&amp;login=false\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>2018 <em>American Journal of Epidemiology<\/em> Review:<\/strong><\/a> Combined data from seven retrospective cohort studies, including over 130,000 mother\u2013child pairs. Researchers found small, but statistically significant associations between prenatal acetaminophen exposure and increased risk of ADHD and autism spectrum disorder. The risk appeared slightly higher with longer or more frequent use, though the authors cautioned that the evidence was observational, and limited by recall bias and unmeasured confounding factors [3].<\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41574-021-00553-7\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>2021 Consensus Statement<\/strong> <strong>in <em>Nature Reviews Endocrinology<\/em> <\/strong><\/a>(91 scientists): Called for more transparency, warning that data pointed to possible risks and urging pregnant women not to use acetaminophen indiscriminately [4].<\/li>\n\n\n\n<li><a href=\"https:\/\/naturalwomanhood.org\/tylenol-use-during-pregnancy\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>2023 article by Natural Womanhood<\/strong><\/a>: Picked up on these signals, noting that women often bore the burden of navigating confusing information; a mix of \u201cdon\u2019t worry, it\u2019s safe\u201d from doctors and \u201cbut maybe not\u201d from emerging science.<\/li>\n\n\n\n<li><strong><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2817406?utm_source=chatgpt.com#google_vignette\">2024 Swiss registry study in <em>JAMA<\/em><\/a><\/strong>: Analyzed data from over 2 million children and initially observed a modest correlation between maternal acetaminophen use and autism spectrum disorder. However, this association vanished in sibling-control models, indicating no causal relationship once shared familial factors were accounted for [5].<\/li>\n<\/ul>\n\n\n\n<p>Together, these studies and commentaries painted a picture: maybe Tylenol wasn\u2019t as harmless as once thought. But each came with significant limitations to making definitive statements about the safety of Tylenol use in pregnancy: small cohorts, reliance on maternal recall, or statistical noise.<\/p>\n\n\n\n<figure class=\"wp-block-pullquote\"><blockquote><p>Together, these studies and commentaries painted a picture: maybe Tylenol wasn\u2019t as harmless as once thought. But each came with significant limitations to making definitive statements about the safety of Tylenol use in pregnancy: small cohorts, reliance on maternal recall, or statistical noise.<\/p><\/blockquote><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-enter-mt-sinai-harvard-why-their-review-of-the-data-stands-out\"><span id=\"enter-mt-sinai-harvard-why-their-review-of-the-data-stands-out\">Enter Mt. Sinai\/Harvard: Why their review of the data stands out<\/span><\/h2>\n\n\n\n<p>The <strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40804730\/\">2025 Mt. Sinai\/Harvard systematic review<\/a><\/strong> is different [1]. Here\u2019s why it matters:<\/p>\n\n\n\n<p><strong>Scale:<\/strong> The team screened decades of research and identified 46 human studies examining prenatal acetaminophen exposure and child neurodevelopment. Among these, 27 studies reported significant associations between maternal use and disorders such as ADHD and autism; 9 showed no association, and 4 suggested protective effects. Collectively, these studies encompassed millions of mother\u2013child pairs across multiple countries. That diversity of data reduces the chance that cultural or methodological bias from any single study could skew the outcome.<\/p>\n\n\n\n<p><strong>Methodology: <\/strong>The researchers applied the Navigation Guide, a rigorous framework originally designed for environmental health science. Instead of selectively citing studies, this method systematically evaluates every piece of available evidence, grades its quality, and then determines the overall strength of the body of research.<\/p>\n\n\n\n<p><strong>Consistency: <\/strong>Despite differences in design, ranging from large national cohorts to case\u2013control and sibling-controlled analyses, the same pattern persisted: prenatal acetaminophen exposure correlated with elevated risks of ADHD and autism spectrum disorders. Higher-quality studies, including those using biomarkers of exposure, were more likely to detect these associations.<\/p>\n\n\n\n<p><strong>Strength of Evidence: <\/strong>Earlier reviews had labeled the evidence as \u201climited\u201d or \u201csuggestive.\u201d The Mt. Sinai\/Harvard team upgraded it to \u201csufficient evidence of developmental risk,\u201d the strongest level achievable without experimental proof. In plain terms, that means the link is consistent, reproducible, and unlikely to be due to chance.<\/p>\n\n\n\n<p><strong>In short: <\/strong>The Mt. Sinai\/Harvard review didn\u2019t expose a brand-new danger; instead, it confirmed with far greater confidence what a decade of research had already been warning. And that\u2019s precisely why Secretary Kennedy\u2019s call for caution resonated: not because a single bombshell study dropped, but because the accumulated evidence finally became too substantial to ignore.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-what-this-doesn-t-mean\"><span id=\"what-this-doesnt-mean\">What this doesn\u2019t mean<\/span><\/h3>\n\n\n\n<p>It\u2019s worth pausing here. The Mt. Sinai\/Harvard study does <strong>not<\/strong> mean:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>That Tylenol causes autism or ADHD in every case.<br><\/li>\n\n\n\n<li>That avoiding Tylenol will drop autism rates to zero.<br><\/li>\n\n\n\n<li>That women who used Tylenol in pregnancy \u201ccaused\u201d their child\u2019s challenges.<\/li>\n<\/ul>\n\n\n\n<p>Autism is complex, with roots in genetics, prenatal health, environmental exposures, and factors we still don\u2019t understand. Tylenol may be one piece of the puzzle, not the whole picture.<\/p>\n\n\n\n<figure class=\"wp-block-pullquote\"><blockquote><p>Autism is complex, with roots in genetics, prenatal health, environmental exposures, and factors we still don\u2019t understand. Tylenol may be one piece of the puzzle, not the whole picture.<\/p><\/blockquote><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-the-risk-conversation\"><span id=\"the-risk-conversation\">The risk conversation<\/span><\/h2>\n\n\n\n<p>This is where it gets complicated. Medicine often deals in absolutes: \u201csafe\u201d or \u201cunsafe.\u201d But life doesn\u2019t work that way.<\/p>\n\n\n\n<p>Acetaminophen may still be the least risky pharmaceutically manufactured pain reliever available to pregnant women. Uncontrolled fever or unmanaged pain also carry significant risks to both mother and baby. For some women, Tylenol may remain the best choice.<\/p>\n\n\n\n<p>Others may choose to avoid it entirely, <a href=\"https:\/\/naturalwomanhood.org\/pregnancy-pain-relief\/\" target=\"_blank\" rel=\"noreferrer noopener\">using hydration, rest, or non-pharmaceutical remedies<\/a> instead. Both responses are valid, but the conversation around Tylenol may encourage women to try to manage illnesses without pharmaceuticals while pregnant and only introduce acetaminophen (or any other medication approved by their doctor) when absolutely needed\u2014and sometimes, they absolutely <em>are<\/em> needed!&nbsp;<\/p>\n\n\n\n<p>As Natural Womanhood has often emphasized, women deserve <strong>full information and full autonomy<\/strong>, not medical paternalistic reassurances or fearmongering.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-pregnancy-orthorexia-and-the-illusion-of-zero-risk\"><span id=\"pregnancy-orthorexia-and-the-illusion-of-zero-risk\">Pregnancy orthorexia and the illusion of zero risk<\/span><\/h2>\n\n\n\n<p>There\u2019s also a cultural trap worth naming: orthorexia, the obsession with eating or living in a way that eliminates all possible risk.<\/p>\n\n\n\n<p>Applied to pregnancy\u2013as <a href=\"https:\/\/naturalwomanhood.org\/podcast\/nw-podcast-s2-ep-8-making-space-for-womens-bodies\/\" target=\"_blank\" rel=\"noreferrer noopener\">Leah Libresco Sargeant<\/a> put it <a href=\"https:\/\/x.com\/LeahLibresco\/status\/1970261748482773473\" target=\"_blank\" rel=\"noreferrer noopener\">on X<\/a>\u2013&#8221;pregnancy orthorexia&#8221; could look like refusing Tylenol at all costs, even when a 102-degree fever threatens fetal health. Just as chasing a \u201cperfectly clean\u201d diet can harm more than it helps, chasing zero medical risk is impossible, misguided, and potentially dangerous.<\/p>\n\n\n\n<p>The truth is less dramatic but more humane: health decisions are a matter of risk assessment, not risk elimination.<\/p>\n\n\n\n<figure class=\"wp-block-pullquote\"><blockquote><p>The truth is less dramatic but more humane: health decisions are a matter of risk assessment, not risk elimination.<\/p><\/blockquote><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-why-the-secretary-of-health-and-human-services-is-speaking-up-now\"><span id=\"why-the-secretary-of-health-and-human-services-is-speaking-up-now\">Why the Secretary of Health and Human Services is speaking up now<\/span><\/h2>\n\n\n\n<p>So why the sudden attention on Tylenol and autism?<\/p>\n\n\n\n<p>In short: Because the Mt. Sinai\/Harvard study marks a tipping point. The signal of risk is now backed by enough evidence that ignoring it would be irresponsible. Importantly, Secretary Kennedy\u2019s announcement doesn\u2019t <em>ban<\/em> Tylenol, but it does acknowledge uncertainty in a way government health agencies rarely do.<\/p>\n\n\n\n<p>In practical terms, it means:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Doctors may start advising women to limit Tylenol to the lowest effective dose and shortest duration possible.<br><\/li>\n\n\n\n<li>Pregnant women may be encouraged to try alternatives first.<br><\/li>\n\n\n\n<li>Research into safer pain relief options for pregnancy may accelerate.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-women-deserve\"><span id=\"what-women-deserve\">What women deserve<\/span><\/h2>\n\n\n\n<p>At the heart of this conversation is not just Tylenol, but trust. For too long, women have been told: \u201cIt\u2019s fine, don\u2019t worry,\u201d only to later learn <a href=\"https:\/\/verilymag.com\/culture\/covid-19-clinical-trials-exclude-pregnant-breastfeeding-menstruating-women-2021\/\" target=\"_blank\" rel=\"noreferrer noopener\">the story was far more complicated<\/a>. That breeds both fear and resentment.<\/p>\n\n\n\n<p>What women need is clarity without condescension. Acknowledgment of uncertainty and space to weigh risks for themselves. Pregnancy already comes with a thousand decisions and sacrifices; Tylenol should not become another source of guilt. Instead, choosing to use Tylenol given one\u2019s unique health situation and tolerance for risk should be an example of what informed, autonomous decision-making looks like in practice.<\/p>\n\n\n\n<p>What the Tylenol controversy shows most clearly is that women need better information to make informed decisions in (and outside) of pregnancy. And given the complicated nature of autism, ADHD, and other neurodevelopmental disorders, the conversation shouldn\u2019t end at possible <em>in-utero<\/em> exposures that might lead to their development.\u00a0As Anne Marie Williams explained in her <a href=\"https:\/\/naturalwomanhood.org\/tylenol-use-during-pregnancy\/\" target=\"_blank\" rel=\"noreferrer noopener\">2023 Natural Womanhood piece<\/a> on the safety of Tylenol in pregnancy: <\/p>\n\n\n\n<p>&#8220;Detecting a link between Tylenol consumption and risk of autism and\/or ADHD and then quantifying that risk is complicated because, as the American College of Obstetricians and Gynecologists (ACOG) points out, factors after birth can play a role in the childhood development of neurological disorders in addition to in-utero exposures. Certainly, genetic vulnerability plays some role in the development of autism, with or without Tylenol use, acknowledges Dr. Roberta Ness, the same epidemiologist who raised the alarm about talcum powder (baby powder) use potentially leading to increased risk of ovarian cancer. In other words, while there is some compelling evidence linking Tylenol use and autism\/ADHD, more research is needed in this area.&#8221;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-the-bottom-line-on-using-tylenol-in-pregnancy\"><span id=\"the-bottom-line-on-using-tylenol-in-pregnancy\">The bottom line on using Tylenol in pregnancy<\/span><\/h2>\n\n\n\n<p>The Mt. Sinai\/Harvard study doesn\u2019t demand panic. It demands perspective.<\/p>\n\n\n\n<p>Yes, acetaminophen is no longer the unquestionably safe option it once was. But no, it is not an unmitigated poison to always be feared. Like most things in health and medicine, Tylenol lives in the gray zone, a tool with both benefits and risks. And that should be the real message: not that certainty exists, but that women should be given the information they need, so they can navigate that uncertainty with due consideration of their particular life circumstances and tolerance for risk.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-pullquote\"><blockquote><p>Like most things in health and medicine, Tylenol lives in the gray zone, a tool with both benefits and risks.<\/p><\/blockquote><\/figure>\n\n\n\n<p><strong>References<\/strong><\/p>\n\n\n\n[1] Prada D, Ritz B, Bauer AZ, Baccarelli AA. Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology. Environ Health. 2025 Aug 14;24(1):56. doi: 10.1186\/s12940-025-01208-0. PMID: 40804730; PMCID: PMC12351903.<\/p>\n\n\n\n[2] Liew Z, Ritz B, Rebordosa C, Lee PC, Olsen J. Acetaminophen use during pregnancy, behavioral problems, and hyperkinetic disorders. JAMA Pediatr. 2014 Apr;168(4):313-20. doi: 10.1001\/jamapediatrics.2013.4914. PMID: 24566677.<\/p>\n\n\n\n[3] Masarwa R, Levine H, Gorelik E, Reif S, Perlman A, Matok I. Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies. Am J Epidemiol. 2018 Aug 1;187(8):1817-1827. doi: 10.1093\/aje\/kwy086. PMID: 29688261.<\/p>\n\n\n\n[4] Bauer, A.Z., Swan, S.H., Kriebel, D.&nbsp;<em>et al.<\/em>&nbsp;Paracetamol use during pregnancy \u2014 a call for precautionary action.&nbsp;<em>Nat Rev Endocrinol<\/em>&nbsp;<strong>17<\/strong>, 757\u2013766 (2021). https:\/\/doi.org\/10.1038\/s41574-021-00553-7<\/p>\n\n\n\n[5] Ahlqvist VH, Sj\u00f6qvist H, Dalman C, Karlsson H, Stephansson O, Johansson S, Magnusson C, Gardner RM, Lee BK. Acetaminophen Use During Pregnancy and Children&#8217;s Risk of Autism, ADHD, and Intellectual Disability. JAMA. 2024 Apr 9;331(14):1205-1214. doi: 10.1001\/jama.2024.3172. PMID: 38592388; PMCID: PMC11004836.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"Un examen approfondi des preuves","protected":false},"author":141,"featured_media":23574,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","csco_singular_sidebar":"","csco_page_header_type":"","csco_page_load_nextpost":"","csco_post_video_location":[],"csco_post_video_url":"","csco_post_video_bg_start_time":0,"csco_post_video_bg_end_time":0,"footnotes":""},"categories":[5185,5352],"tags":[4456],"class_list":{"0":"post-23572","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-pregnancy-childbirth","8":"category-pregnancy-health","9":"tag-healthy-pregnancy","10":"cs-entry","11":"cs-video-wrap"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Tylenol in pregnancy: Can it really cause autism? - Natural Womanhood<\/title>\n<meta name=\"description\" content=\"How should women make sense of what the new review says about Tylenol in pregnancy? 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