{"id":22412,"date":"2025-03-29T08:00:00","date_gmt":"2025-03-29T13:00:00","guid":{"rendered":"https:\/\/naturalwomanhood.org\/?p=22412"},"modified":"2025-04-29T11:18:13","modified_gmt":"2025-04-29T16:18:13","slug":"paraben-cancer-du-sein","status":"publish","type":"post","link":"https:\/\/naturalwomanhood.org\/fr\/paraben-breast-cancer\/","title":{"rendered":"Vos produits de soin de la peau peuvent-ils augmenter votre risque de cancer du sein ?"},"content":{"rendered":"\n<p>As I was scrolling through Instagram one day, I came across a click-bait post shared by a friend in her stories. The title read, \u201cNew study finds skincare ingredients are linked to breast cancer.\u201d<\/p>\n\n\n\n<p>As a former breast cancer and immunology researcher, the post\u2014which linked to a <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0045653523002813\" target=\"_blank\" rel=\"noreferrer noopener\">research study<\/a>\u2014naturally caught my eye [1]. You\u2019re no doubt already familiar with the consumer push for \u201cclean beauty\u201d products, and a growing awareness that the ingredients in our cosmetics, skincare, and body care products might actually matter. Scientists, motivated by increased pressure from consumers and skincare developers alike, have also tried to understand how ingredients may affect our health.\u00a0<\/p>\n\n\n\n<p>But how worried do you need to be about your skin care products and breast cancer risk?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-researchers-explored-whether-parabens-and-phthalates-affect-cancer-risk\"><span id=\"researchers-explored-whether-parabens-and-phthalates-affect-cancer-risk\">Researchers explored whether parabens and phthalates affect cancer risk<\/span><\/h2>\n\n\n\n<p>This particular study was conducted in collaboration with <a href=\"https:\/\/www.breastcancerovertime.org\" target=\"_blank\" rel=\"noreferrer noopener\">Breast Cancer Over Time<\/a>, a nonprofit group funding community-based research. Two of the study authors are involved with this group, one is a breast cancer survivor and the other is a public health scientist. The collaboration allowed the research investigators to recruit study participants from a pool of women who are passionate about breast cancer research and risk reduction.<\/p>\n\n\n\n<p>The investigators recruited 41 female participants who regularly used skincare products that contained parabens or phthalates. Excitingly, they had 100% compliance, meaning all of the women followed all the requirements of the study, which is pretty rare!.&nbsp;<\/p>\n\n\n\n<p>The 41 women were randomized into two groups. One group\u2013the control group\u2013kept using their same skincare, body care, and makeup products as usual. The other group was given skincare, body care, and makeup products free from paraben or phthalates.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-parabens-and-phthalates-two-skincare-ingredients-that-might-act-like-estrogen-in-the-body\"><span id=\"parabens-and-phthalates-two-skincare-ingredients-that-might-act-like-estrogen-in-the-body\">Parabens and phthalates: two skincare ingredients that might act like estrogen in the body<\/span><\/h2>\n\n\n\n<p>Before we dive into the study results, we need to define what parabens and phthalates are, how they\u2019re related to estrogen, and why all this matters for breast cancer.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-parabens-and-estrogen\"><span id=\"parabens-and-estrogen\">Parabens and estrogen<\/span><\/h3>\n\n\n\n<p>According to the U.S. Food and Drug Administration (<a href=\"https:\/\/www.fda.gov\/cosmetics\/cosmetic-ingredients\/parabens-cosmetics\" target=\"_blank\" rel=\"noreferrer noopener\">FDA<\/a>), parabens are a commonly used preservative in personal care products and cosmetics. Preservatives are important ingredients because they prevent unwanted bacteria and\/or mold growth in your products. Some examples of parabens you might see on a personal care item\u2019s ingredients list include methylparaben, propylparaben, butylparaben, and ethylparaben.<\/p>\n\n\n\n<p>Parabens have the potential to act like the <a href=\"https:\/\/naturalwomanhood.org\/what-is-estrogen-hormone\/\" target=\"_blank\" rel=\"noreferrer noopener\">hormone estrogen<\/a> in the body. Estrogen, along with the hormone progesterone, plays a key role in the female menstrual cycle. Estrogen is responsible for the growth of the uterine lining and formation of peak-type cervical mucus, both of which are necessary for conception to occur.<\/p>\n\n\n\n<p>The FDA <a href=\"https:\/\/www.fda.gov\/cosmetics\/resources-consumers-cosmetics\/cosmetics-safety-qa-parabens\" target=\"_blank\" rel=\"noreferrer noopener\">maintains<\/a> that parabens have much lower estrogenic activity compared to the natural hormone, and have <a href=\"https:\/\/www.fda.gov\/cosmetics\/cosmetic-ingredients\/parabens-cosmetics\" target=\"_blank\" rel=\"noreferrer noopener\">not been shown to be harmful<\/a>. So far, studies in humans have not found strong evidence that parabens cause breast cancer, as explained by the American Cancer Society, <a href=\"https:\/\/www.cancer.org\/cancer\/risk-prevention\/chemicals\/antiperspirants-and-breast-cancer-risk.html\" target=\"_blank\" rel=\"noreferrer noopener\">here<\/a>. Some organizations and research groups, however, like the Environmental Working Group (EWG, a non-profit activist group) <a href=\"https:\/\/www.ewg.org\/what-are-parabens\" target=\"_blank\" rel=\"noreferrer noopener\">claim<\/a> parabens have potentially harmful endocrine-disrupting activity. They assert that these ingredients may be doing more in our bodies than just preventing bacterial growth on or in our skincare products.\u00a0<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-phthalates-and-estrogen\"><span id=\"phthalates-and-estrogen\">Phthalates and estrogen<\/span><\/h3>\n\n\n\n<p><a href=\"https:\/\/www.fda.gov\/cosmetics\/cosmetic-ingredients\/phthalates-cosmetics\" target=\"_blank\" rel=\"noreferrer noopener\">Phthalates<\/a> are a class of chemicals used in a broad variety of products including plastics, personal care products, cosmetics, and fragrances. They have functions that make plastics more durable, act as solvents to help ingredients dissolve properly in a formulation, and help ingredients \u201cstick\u201d on your skin\u2013as in the case of fragrance.\u00a0<\/p>\n\n\n\n<p>The FDA provides maximum amounts of phthalates that can be used in consumer products, and according to the available data, also considers <a href=\"https:\/\/www.fda.gov\/cosmetics\/cosmetic-ingredients\/phthalates-cosmetics\" target=\"_blank\" rel=\"noreferrer noopener\">these ingredients safe<\/a>. However, like parabens, phthalates are <a href=\"https:\/\/www.ewg.org\/news-insights\/news\/2024\/09\/what-are-phthalates\" target=\"_blank\" rel=\"noreferrer noopener\">known endocrine disruptors<\/a>. Phthalate exposure may contribute to <a href=\"https:\/\/naturalwomanhood.org\/simple-ways-to-protect-your-health-and-fertility-from-endocrine-disruptors\/\" target=\"_blank\" rel=\"noreferrer noopener\">heavy periods<\/a>, irregular cycles, abnormal cervical mucus patterns, endometriosis, infertility, and even cancer.\u00a0 Phthalate exposure can be particularly damaging during <a href=\"https:\/\/naturalwomanhood.org\/phthalates-preterm-birth\/\" target=\"_blank\" rel=\"noreferrer noopener\">pregnancy<\/a>, leading to increased risk of <a href=\"https:\/\/naturalwomanhood.org\/phthalates-preterm-birth-2\/\" target=\"_blank\" rel=\"noreferrer noopener\">preterm birth<\/a>. Phthalates have also been shown to have endocrine-disrupting effects in <a href=\"https:\/\/naturalwomanhood.org\/protecting-boys-from-feminizing-chemicals-male-endocrine-disruptors\/\" target=\"_blank\" rel=\"noreferrer noopener\">males<\/a>, lowering testosterone levels and even disrupting <a href=\"https:\/\/naturalwomanhood.org\/simple-ways-to-protect-your-health-and-fertility-from-endocrine-disruptors\/\" target=\"_blank\" rel=\"noreferrer noopener\">sperm quality<\/a>, affecting male fertility.\u00a0<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-why-are-estrogens-related-to-breast-cancer\"><span id=\"why-are-estrogens-related-to-breast-cancer\">Why are estrogens related to breast cancer?<\/span><\/h3>\n\n\n\n<p>The hormone estrogen is crucial for female sexual maturation, including the development of breast tissue. The cells in your breasts have receptors that bind to the hormone estrogen. That\u2019s why when your body has an increase in estrogen during puberty, your breasts grow and develop.&nbsp;<\/p>\n\n\n\n<p>Some cells in your breasts that could become cancerous also have these estrogen receptors. If these cells become cancerous, we say you have estrogen-receptor positive (ER+) <a href=\"https:\/\/www.cancer.org\/cancer\/types\/breast-cancer\/understanding-a-breast-cancer-diagnosis\/breast-cancer-hormone-receptor-status.html\" target=\"_blank\" rel=\"noreferrer noopener\">breast cancer<\/a>. This means estrogen can \u201cturn on\u201d cancer cells that have receptors for the estrogen hormone, thus acting as a signal for the cancer cells to divide.\u00a0<\/p>\n\n\n\n<p>While parabens aren\u2019t estrogens, they can mimic the hormone estrogen in your body. Thus, they\u2019re referred to as <em>xenoestrogens<\/em>. <em>Xeno<\/em> comes from the Greek word meaning \u201cforeign,\u201d so a xenoestrogen is any external source of estrogen activity in your body. As the thinking goes, products containing estrogen-like chemicals, like parabens, could exacerbate this estrogenic activity and potentially contribute to breast cancer.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-did-the-study-find-that-parabens-or-phthalates-affect-breast-cancer-risk\"><span id=\"did-the-study-find-that-parabens-or-phthalates-affect-breast-cancer-risk\">Did the study find that parabens or phthalates affect breast cancer risk?<\/span><\/h2>\n\n\n\n<p>Now, let\u2019s get back to our research study. The researchers were interested in what, if any, role parabens and phthalates might have in breast cancer development. There were two main questions the study aimed to answer:&nbsp;<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Are parabens and phthalates from skincare products detectable in the body?<\/li>\n\n\n\n<li>Do these parabens and phthalates have any affect on breast tissue and cancer development?<\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-the-ingredients-in-our-products-are-detectable-in-our-urine\"><span id=\"the-ingredients-in-our-products-are-detectable-in-our-urine\">The ingredients in our products are detectable in our urine<\/span><\/h3>\n\n\n\n<p>To answer the first question, scientists assessed the urine of study participants for paraben and phthalate levels. Then, they wanted to know if swapping out the participant\u2019s personal care products measurably reduced the levels of parabens and phthalates found in the participants\u2019 urine.&nbsp;<\/p>\n\n\n\n<p>First, the scientists <em>did <\/em>detect several different parabens and phthalates in the urine of participants. They also saw significantly lower levels of several parabens and one phthalate in the study participants 28 days after switching up the participants\u2019 product regimen to paraben- and phthalate-free products.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-pullquote\"><blockquote><p>First, the scientists <em>did <\/em>detect several different parabens and phthalates in the urine of participants. They also saw significantly lower levels of several parabens and one phthalate in the study participants 28 days after switching up the participants\u2019 product regimen to paraben- and phthalate-free products.<\/p><\/blockquote><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-parabens-and-phthalates-affected-some-gene-expression\"><span id=\"parabens-and-phthalates-affected-some-gene-expression\">Parabens and phthalates affected some gene expression<\/span><\/h3>\n\n\n\n<p>For the \u201cmeat\u201d of their study, the investigators assessed whether paraben- and phthalate-containing products had any effect on cancer-associated genes. These are genes that tend to be turned on (have higher expression) or turned off (have lower expression) in breast cancer cells or tumors.&nbsp;<\/p>\n\n\n\n<p>Some genes are protective against cancer, and are turned <em>off <\/em>in cancer cells so the cancer can spread. Other genes are helpful for the cancer to spread aggressively\u2013these genes can be turned <em>on<\/em>, or upregulated, in cancer cells.<\/p>\n\n\n\n<p>Of the 41 total study participants (<em>all<\/em> of whom, prior to the beginning of the study, used personal care products with parabens and phthalates), the researchers obtained samples of breast tissue cells from 36 women before and after they switched their personal care products. Twenty of these samples were acceptable for further analysis.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-28-days-to-change-gene-expression\"><span id=\"28-days-to-change-gene-expression\">28 days to change gene expression?<\/span><\/h3>\n\n\n\n<p>From these 20 samples, the researchers looked at 26 genes that are relevant to cancer. They found 19 of these genes changed to \u201cnormal\u201d levels in the women who switched their care products to ones that were paraben- and phthalate free. <em>Interestingly, it only took 28 days to \u201creset\u201d the gene expression with paraben- and phthalate-free products.<\/em>&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-pullquote\"><blockquote><p>From these 20 samples, the researchers looked at 26 genes that are relevant to cancer. They found 19 of these genes changed to \u201cnormal\u201d levels in the women who switched their care products to ones that were paraben- and phthalate free. <em>Interestingly, it only took 28 days to \u201creset\u201d the gene expression with paraben- and phthalate-free products.<\/em>\u00a0<\/p><\/blockquote><\/figure>\n\n\n\n<p>Finally, the researchers wanted to see if the paraben and phthalate metabolites could have an effect on biological processes, which would reflect an interaction between multiple genes and proteins in the body. They used a database and sets of genes that are known to interact together (called pathways) and found the PI3K-AKT pathway had the most significant change after the skincare product swap. This pathway is important because it plays a role in cell survival, growth, and avoiding cell death, processes often disrupted in breast cancer.&nbsp;<\/p>\n\n\n\n<p>Overall, the changes observed from swapping out paraben- and phthalate-containing skincare products seemed to create a healthier environment in the body by counteracting factors that could promote cancer.<\/p>\n\n\n\n<figure class=\"wp-block-pullquote\"><blockquote><p>Overall, the changes observed from swapping out paraben- and phthalate-containing skincare products seemed to create a healthier environment in the body by counteracting factors that could promote cancer.<\/p><\/blockquote><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-the-trial-didn-t-tell-us\"><span id=\"what-the-trial-didnt-tell-us\">What the trial didn\u2019t tell us<\/span><\/h2>\n\n\n\n<p>There are several key points to keep in mind when interpreting these results. The first is, if a substance is found in your urine, that means your body is absorbing, processing, and then excreting it. This is precisely the function of our <a href=\"https:\/\/www.niddk.nih.gov\/health-information\/kidney-disease\/kidneys-how-they-work\" target=\"_blank\" rel=\"noreferrer noopener\">kidneys<\/a>. Thus, if something is found in urine, that doesn\u2019t automatically make it harmful or bad.\u00a0<\/p>\n\n\n\n<p>Additionally, we were given no frame of reference for whether the levels of parabens and phthalates found in the participants were<em> high<\/em>, just that they were <em>detected <\/em>and then <em>reduced <\/em>with product swaps.&nbsp;<\/p>\n\n\n\n<p>What\u2019s more, this study examined a very small number of participants, even though they had impressive compliance from all of them. While research studies on humans are more informative than those on cells in a dish or on animal models, a sample size of 41 women (and only 14 for the gene expression experiments) is too small to make a strong claim about the effects of any of the studied ingredients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-why-we-still-don-t-know-whether-parabens-and-phthalates-in-skincare-products-cause-breast-cancer\"><span id=\"why-we-still-dont-know-whether-parabens-and-phthalates-in-skincare-products-cause-breast-cancer\">Why we still don\u2019t know whether parabens and phthalates in skincare products cause breast cancer<\/span><\/h2>\n\n\n\n<p>Lastly, the study focused on gene expression and cancer-associated genotypes, or patterns. They did not ask or show any direct causal effect of paraben- and phthalate-containing products on the development of breast cancer. They merely identified some genes that are active in <em>some<\/em> breast cancers. Just because certain genes are turned on or off does not mean you will or won\u2019t develop breast cancer\u2013or any type of cancer.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-does-this-mean-for-you\"><span id=\"what-does-this-mean-for-you\">What does this mean for you?<\/span><\/h2>\n\n\n\n<p>I personally like to choose products that are paraben-free when available. I also prefer fragrance-free products for my body and home. However, some products\u2013particularly prescriptions that might be recommended by a dermatologist\u2013<em>do<\/em> contain parabens because these ingredients have been generally recognized as safe by the FDA. I will personally continue to use these products without fear.<\/p>\n\n\n\n<p>If you are concerned, feel free to swap out skincare products as your budget allows or as you run out of them. You can reference the <a href=\"https:\/\/www.ewg.org\/skindeep\/\" target=\"_blank\" rel=\"noreferrer noopener\">EWG database<\/a> for information about the ingredients these products contain. (You should know that ingredients can be absorbed by your skin, however the doses studied in many trials are much higher than would be absorbed.)\u00a0<\/p>\n\n\n\n<p>This study demonstrates that ingredients <em>can<\/em> affect gene expression. To what extent biologically? That we don\u2019t know yet. Much more research is needed before we can say parabens and\/or phthalates <em>cause<\/em> or even <em>increase <\/em>your risk of breast cancer. The <a href=\"https:\/\/www.cancer.org\/cancer\/risk-prevention\/chemicals\/cosmetics.html\" target=\"_blank\" rel=\"noreferrer noopener\">American Cancer Society<\/a> sums up this grey area nicely and \u201csupports the need for open and transparent regulatory oversight of cosmetics and encourages continued and expanded scientific research on the potential links between cosmetic use and cancer risk.\u201d\u00a0<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-additional-reading\"><span id=\"additional-reading\">Additional reading:<\/span><\/h4>\n\n\n\n<p><a href=\"https:\/\/naturalwomanhood.org\/phthalates-preterm-birth\/\">What\u2019s the connection between phthalates and preterm birth?<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-references\"><span id=\"references\">References:<\/span><\/h4>\n\n\n\n[1] Dairkee SH, Moore DH, Luciani MG, Anderle N, Gerona R, Ky K, Torres SM, Marshall PV, Goodson Iii WH. Reduction of daily-use parabens and phthalates reverses accumulation of cancer-associated phenotypes within disease-free breast tissue of study subjects. Chemosphere. 2023 May;322:138014. doi: 10.1016\/j.chemosphere.2023.138014.<\/p>\n\n\n\n[2] Wang L, Chen L, Schlenk D, Li F, Liu J. Parabens promotes invasive properties of multiple human cells: A potential cancer-associated adverse outcome pathway. Sci Total Environ. 2024 May 20;926:172015. doi: 10.1016\/j.scitotenv.2024.172015.<\/p>\n\n\n\n[3] Wei F, Mortimer M, Cheng H, Sang N, Guo LH. Parabens as chemicals of emerging concern in the environment and humans: A review. Sci Total Environ. 2021 Jul 15;778:146150. doi: 10.1016\/j.scitotenv.2021.146150.<\/p>\n","protected":false},"excerpt":{"rendered":"Les parab\u00e8nes et les phtalates sont tr\u00e8s pr\u00e9sents dans le maquillage et les produits de soins corporels.","protected":false},"author":120,"featured_media":22413,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","csco_singular_sidebar":"","csco_page_header_type":"","csco_page_load_nextpost":"","csco_post_video_location":[],"csco_post_video_url":"","csco_post_video_bg_start_time":0,"csco_post_video_bg_end_time":0,"footnotes":""},"categories":[5366,5177],"tags":[4068,6310,6309],"class_list":{"0":"post-22412","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-hormone-imbalance","8":"category-know-your-body","9":"tag-breast-cancer","10":"tag-endocrine-disrupting-chemicals","11":"tag-endocrine-disruptor","12":"cs-entry","13":"cs-video-wrap"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Could your skincare products raise your breast cancer risk? - Natural Womanhood<\/title>\n<meta name=\"description\" content=\"Could parabens and phthalates in your skincare products raise your breast cancer risk? 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