{"id":22020,"date":"2025-01-02T08:00:00","date_gmt":"2025-01-02T14:00:00","guid":{"rendered":"https:\/\/naturalwomanhood.org\/?p=22020"},"modified":"2025-02-04T11:11:22","modified_gmt":"2025-02-04T17:11:22","slug":"ellura-uti","status":"publish","type":"post","link":"https:\/\/naturalwomanhood.org\/es\/ellura-uti\/","title":{"rendered":"Ellura frente a D-manosa: \u00bfCu\u00e1l es mejor para prevenir las ITU?"},"content":{"rendered":"\n<p>If you\u2019ve ever suffered through a <a href=\"https:\/\/naturalwomanhood.org\/why-do-i-keep-getting-utis-a-review-of-causes-and-treatments\/\">UTI (urinary tract infection)<\/a>, you probably remember the tell-tale signs: feeling like you need to urinate constantly, a burning sensation when you use the bathroom, or urine that is cloudy or even red-tinged in color. UTIs can be painful and frustrating, especially when you get them often and they just <a href=\"https:\/\/www.health.harvard.edu\/bladder-and-bowel\/when-urinary-tract-infections-keep-coming-back\">keep coming back<\/a>.<\/p>\n\n\n\n<p>Fortunately, some supplements may be particularly helpful to those who struggle with recurrent UTIs. A commonly-touted supplement for the treatment and prevention of<em> <\/em>UTIs is <a href=\"https:\/\/www.healthline.com\/health\/d-mannose-for-uti\">D-mannose<\/a>, a simple sugar closely related to glucose. Some evidence <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8944421\/\">suggests<\/a> that D-mannose can be beneficial in preventing<em> E. coli<\/em> bacteria from attaching to the urinary tract [1].&nbsp;<\/p>\n\n\n\n<p>Still, other large trials <a href=\"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2817488?utm_source=press_release&amp;utm_medium=press_release&amp;utm_campaign=ellura_d_mannose_2024_07_22&amp;utm_content=ellura\">found<\/a> that D-mannose had little effect in mitigating UTI risk [2]. A recent small <a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19390211.2024.2356592#abstract\">study<\/a> from Rutgers University compared D-mannose to another supplement,\u00a0a <a href=\"https:\/\/hcp.solvwellness.com\/ellura\/\">hyper-concentrated form<\/a> of cranberry juice extract called Ellura [3]. Study results suggest that Ellura may be more effective than D-mannose at preventing urinary tract infections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-did-the-researchers-study\"><span id=\"what-did-the-researchers-study\">What did the researchers study?<\/span><\/h2>\n\n\n\n<p>In the Rutgers study, researchers were interested in comparing D-mannose to the concentrated cranberry supplement Ellura to see whether and how much each supplement stimulated anti-adhesion activity (AAA) against the two kinds of <em>E. coli<\/em> bacteria that most commonly cause UTIs [3]. They studied the urine of 20 participants who took either Ellura or D-Mannose for just one week. Samples that contained AAA meant the supplement was effective in preventing <em>E. coli<\/em> bacteria from adhering to the urinary tract (and causing an infection).&nbsp;<\/p>\n\n\n\n<p>Study participants were healthy men and women between the ages of 25 and 60 who did not have a history of recurrent UTIs. They were instructed to keep their fluid consumption consistent over the course of the study. Participants took their assigned supplement (either D-mannose or Ellura) and then switched to the other during the second phase of the trial. Each participant collected a total of 30 urine samples, and all were tested for their bacterial anti-adhesion activity (AAA). Participants took each supplement for one week while they collected their urine, plus had a five day wash-out period where they did not test or take any supplements (to ensure quality control as they switched from one intervention to the other).&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-ellura-was-the-aaa-winner\"><span id=\"ellura-was-the-aaa-winner\">Ellura was the AAA winner<\/span><\/h2>\n\n\n\n<p>The Rutgers study <a href=\"https:\/\/www.prnewswire.com\/news-releases\/new-study-shows-ellura-uti-supplement-provides-more-consistent-and-broader-benefit-than-d-mannose-against-uti-bacteria-302202753.html?utm_source=MarketingCloud&amp;utm_medium=email&amp;utm_campaign=Consumer_Ellura_vs_D_Mannose_EM01&amp;utm_content=https%3a%2f%2fwww.prnewswire.com%2fnews-releases%2fnew-study-shows-ellura-uti-supplement-provides-more-consistent-and-broader-benefit-than-d-mannose-against-uti-bacteria-302202753.html\">found<\/a> that both D-mannose and Ellura caused AAA against certain kinds of <em>E. coli<\/em> bacteria, meaning that <em>both<\/em> supplements can be beneficial in preventing bacteria from adhering to the urinary tract. However, D-mannose did<em> not <\/em>prevent the adhesion of P-type <em>E. coli <\/em>in urine, which can potentially cause kidney infections (pyelonephritis). It did create AAA against another type of <em>E. coli <\/em>known as Type 1, but it did so inconsistently and researchers suspect it was not entirely due to the D-mannose. Overall, researchers found that D-mannose had glaring limitations in preventing UTIs.&nbsp;<\/p>\n\n\n\n<p>Ellura, on the other hand, was found to significantly and consistently prevent the adhesion of both P-type and Type 1 <em>E. coli<\/em> bacteria. Researchers concluded that Ellura can \u201cprovide more consistent, broad-spectrum AAA against both P-type and Type-1 uropathogenic <em>E. coli<\/em> with low potential side effects when compared to D-mannose products taken on a daily basis for maintenance of urinary tract health\u201d [3].&nbsp;<\/p>\n\n\n\n<p>These results are not only promising for those who struggle with frequent UTIs and are looking for a solution. They may also be welcome news to the general population, as UTIs are increasingly <a href=\"https:\/\/www.health.harvard.edu\/blog\/antibiotic-resistant-urinary-tract-infections-are-on-the-rise-2019101417982\">resistant to antibiotics<\/a>, the typical treatment. Preventing a UTI with a supplement like Ellura is much simpler than treating an infection <em>after <\/em>it has occurred, and prevents the need for repeated antibiotic use.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-is-ellura-the-same-as-other-cranberry-supplements-or-drinking-cranberry-juice\"><span id=\"is-ellura-the-same-as-other-cranberry-supplements-or-drinking-cranberry-juice\">Is Ellura the same as other cranberry supplements or drinking cranberry juice?<\/span><\/h2>\n\n\n\n<p>The next important questions are: what exactly is Ellura, and is it just the same as any other cranberry supplement (like <a href=\"https:\/\/www.cvs.com\/shop\/azo-cranberry-urinary-tract-health-tablets-50-ct-prodid-134045?skuId=134045&amp;cgaa=QWxsb3dHb29nbGVUb0FjY2Vzc0NWU1BhZ2Vz&amp;cid=ps_vit_pla&amp;gclid=Cj0KCQjwmt24BhDPARIsAJFYKk1Khjyb_LJB3zbCrKsRotCEHT7T7KmD-Du1orZ3Ahb1Nrx-JQKgUjMaAjXoEALw_wcB&amp;gclsrc=aw.ds\">this one<\/a> from Azo) that you can find at the drugstore? In a word, no. Ellura contains 36mg of cranberry proanthocyanidin (PAC), a <a href=\"https:\/\/www.urmc.rochester.edu\/encyclopedia\/content.aspx?contenttypeid=19&amp;contentid=proanthocyanidins#:~:text=General%20description,and%20may%20help%20prevent%20cancer.\">chemical compound<\/a> found in fruit or flowers that have anti-inflammatory or medicinal properties.\u00a0<\/p>\n\n\n\n<p>The main difference between this supplement and others is that while all cranberry supplements include some amount of PAC, other products use the whole cranberry (including the pulp, stems, seeds, and skins). Thus, they are not as concentrated and do not create anti-adhesion activity (AAA) in the same way that a hyper-concentrated form does. Ellura uses <em>only<\/em> cranberry juice extract and each pill contains a standardized 36mg of PAC, which researchers have found to be the required amount to create sufficient AAA to prevent a UTI. Previous <a href=\"https:\/\/www.ajog.org\/article\/S0002-9378(16)30005-9\/fulltext?utm_source=press_release&amp;utm_medium=press_release&amp;utm_campaign=ellura_d_mannose_2024_07_22&amp;utm_content=ellura\">research<\/a> established 36mg of PAC as the necessary threshold, but other supplements do not contain standardized or high amounts of PACs [4].&nbsp;&nbsp;<\/p>\n\n\n\n<p>Another <a href=\"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD001321.pub6\/full\">study<\/a> <a href=\"https:\/\/www.scimex.org\/newsfeed\/a-myth-no-more-cranberry-products-can-prevent-urinary-tract-infections-for-women\">suggested<\/a><em> all<\/em> forms of cranberry could be beneficial to prevent UTIs, finding that&nbsp; 53% of people who have recurring infections can benefit from taking cranberry supplements<em> or<\/em> drinking cranberry juice regularly to prevent new infections [5]. However, this needs to be studied further to fully understand the differences between taking cranberry juice or supplements in forms other than highly potent versions like Ellura.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-the-ellura-vs-d-mannose-study-confirmed-other-findings-of-d-mannose-s-limited-effectiveness\"><span id=\"the-ellura-vs-d-mannose-study-confirmed-other-findings-of-d-mannoses-limited-effectiveness\">The Ellura vs. D-Mannose study confirmed other findings of D-mannose\u2019s limited effectiveness<\/span><\/h2>\n\n\n\n<p>While the Rutgers study does give us promising research about the benefits of taking a concentrated PAC form of cranberry to prevent UTIs, it also pointed out D-mannose\u2019s inconsistency in preventing AAA (which may explain its ineffectiveness). This supports another <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9427198\/#:~:text=D%E2%80%90mannose%20is%20a%20sugar%20which%20is%20part%20of%20a,the%20bladder%20or%20urinary%20tract.\">review of studies<\/a> on the effectiveness of D-mannose, which found the evidence in favor of D-mannose to be minimal and of poor quality [6]. Another large <a href=\"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2817488\">study<\/a> agreed, finding that D-mannose barely outperformed a placebo for UTI prevention [2].&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-we-still-don-t-know-about-ellura-for-uti-prevention\"><span id=\"what-we-still-dont-know-about-ellura-for-uti-prevention\">What we still don\u2019t know about Ellura for UTI prevention<\/span><\/h2>\n\n\n\n<p>More research needs to be done to fully understand the mechanisms behind how both Ellura (and, to a lesser extent, D-mannose) create AAA. The Rutgers study stated that more data is necessary to determine if AAA is higher at different points in the day or if its protection against <em>E. coli<\/em> is sustained and consistent.&nbsp;&nbsp;<\/p>\n\n\n\n<p>A potential blindspot of this study is that while Ellura is largely taken by people who have a history of UTIs and wish to prevent them, the Rutgers study only tested healthy participants who did <em>not<\/em> have an extensive history of urinary tract infections. Further research using participants who have a history of UTIs would be especially helpful to clarify its preventative value against <a href=\"https:\/\/naturalwomanhood.org\/why-do-i-keep-getting-utis-a-review-of-causes-and-treatments\/\">recurrent infections<\/a>.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-takeaways\"><span id=\"takeaways\">Takeaways<\/span><\/h2>\n\n\n\n<p>If you\u2019re prone to frequent urinary tract infections, it might be worth checking out Ellura on top of taking other <a href=\"https:\/\/www.ama-assn.org\/delivering-care\/public-health\/what-doctors-wish-patients-knew-about-uti-prevention\">preventative measures<\/a>. With more and more infections becoming resistant to antibiotics <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance\">as time goes on<\/a>, focusing on prevention is key, especially if you\u2019ve dealt with UTIs in the past.\u00a0<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-references\"><span id=\"references\">References:<\/span><\/h3>\n\n\n\n[1] Wagenlehner F, Lorenz H, Ewald O, Gerke P. Why d-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections-Preliminary Considerations and Conclusions from a Non-Interventional Study. Antibiotics (Basel). 2022 Feb 25;11(3):314. doi: 10.3390\/antibiotics11030314. PMID: 35326777; PMCID: PMC8944421.<\/p>\n\n\n\n[2] Hayward G, Mort S, Hay AD, et al. d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial. <em>JAMA Intern Med.<\/em> 2024;184(6):619\u2013628. doi:10.1001\/jamainternmed.2024.0264<\/p>\n\n\n\n[3] Howell, A. B., Dreyfus, J. F., Bosley, S., Krueger, C. G., Birmingham, A., Reed, J. D., &amp; Chughtai, B. (2024). Differences in P-Type and Type 1 Uropathogenic <em>Escherichia coli<\/em> Urinary Anti-Adhesion Activity of Cranberry Fruit Juice Dry Extract Product and D-Mannose Dietary Supplement. <em>Journal of Dietary Supplements<\/em>, <em>21<\/em>(5), 633\u2013659. <a href=\"https:\/\/doi.org\/10.1080\/19390211.2024.2356592\">https:\/\/doi.org\/10.1080\/19390211.2024.2356592<\/a><\/p>\n\n\n\n[4] Chughtai B, Thomas D, Howell A. Variability of commercial cranberry dietary supplements for the prevention of uropathogenic bacterial adhesion. Am J Obstet Gynecol. 2016 Jul;215(1):122-3. doi: 10.1016\/j.ajog.2016.03.046. Epub 2016 Apr 5. PMID: 27059506.<\/p>\n\n\n\n[5] Williams G, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023 Apr 17;4(4):CD001321. doi: 10.1002\/14651858.CD001321.pub6. Update in: Cochrane Database Syst Rev. 2023 Nov 10;11:CD001321. doi: 10.1002\/14651858.CD001321.pub7. PMID: 37068952; PMCID: PMC10108827.<\/p>\n\n\n\n[6] Cooper TE, Teng C, Howell M, Teixeira-Pinto A, Jaure A, Wong G. D-mannose for preventing and treating urinary tract infections. Cochrane Database Syst Rev. 2022 Aug 30;8(8):CD013608. doi: 10.1002\/14651858.CD013608.pub2. PMID: 36041061; PMCID: PMC9427198.<\/p>\n","protected":false},"excerpt":{"rendered":"Resolver el debate sobre los suplementos de ar\u00e1ndano rojo para la prevenci\u00f3n de las ITU","protected":false},"author":106,"featured_media":22022,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","csco_singular_sidebar":"","csco_page_header_type":"","csco_page_load_nextpost":"","csco_post_video_location":[],"csco_post_video_url":"","csco_post_video_bg_start_time":0,"csco_post_video_bg_end_time":0,"footnotes":""},"categories":[5392,5177,5181],"tags":[6404,6403,5573],"class_list":{"0":"post-22020","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-fitness-and-nutrition","8":"category-know-your-body","9":"category-reproductive-and-menstrual-disorders","10":"tag-ellura","11":"tag-urinary-tract-infection","12":"tag-uti","13":"cs-entry","14":"cs-video-wrap"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Ellura vs. D-mannose: Which is better at preventing UTIs? 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While in college, she was the editor of ISI's Collegiate Network Publication of the Year, The Tower. After graduating, she worked as an elementary school teacher at a classical school before becoming a mother. You can probably find her either shopping for antique books or at home baking all things sourdough. 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