{"id":20517,"date":"2024-04-20T08:00:00","date_gmt":"2024-04-20T13:00:00","guid":{"rendered":"https:\/\/naturalwomanhood.org\/?p=20517"},"modified":"2024-05-07T10:57:51","modified_gmt":"2024-05-07T15:57:51","slug":"resistencia-a-la-progesterona","status":"publish","type":"post","link":"https:\/\/naturalwomanhood.org\/es\/progesterone-resistance\/","title":{"rendered":"\u00bfQu\u00e9 es la resistencia a la progesterona?"},"content":{"rendered":"\n<p>Progesterone, a reproductive hormone released during the luteal phase (second half) of the menstrual cycle, is critical for cycle health, pregnancy, and overall quality of life for women [1]. Restorative reproductive medicine (RRM) has historically emphasized the importance of measuring progesterone levels and understood low progesterone (often referred to as a luteal phase defect) to cause a host of issues. Progesterone supplementation, targeted to the luteal phase of the cycle, has long been a cornerstone of RRM treatment. But some women have normal progesterone levels and <em>still<\/em> have reproductive or other symptoms. For these women, progesterone<em> resistance<\/em> may be at play.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-does-progesterone-do-in-the-female-body-nbsp\"><span id=\"what-does-progesterone-do-in-the-female-body\">What does progesterone do in the female body?&nbsp;<\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/naturalwomanhood.org\/fam-basics-progesterone\/\" target=\"_blank\" rel=\"noreferrer noopener\">Progesterone<\/a> is responsible for relaxing the uterus, normalizing blood sugar, decreasing anxiety, and improving sleep and relaxation. It plays a major role in preparing the lining of the uterus for implantation of a newly conceived life, and is important for the success of early pregnancy. Progesterone also helps balance physiological processes like thyroid and glucose regulation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-progesterone-levels-are-connected-to-some-health-problems\"><span id=\"progesterone-levels-are-connected-to-some-health-problems\">Progesterone levels are connected to some health problems<\/span><\/h2>\n\n\n\n<p>Because of its major role in women\u2019s reproductive health, issues with progesterone can lead to gynecologic and obstetric conditions. Low levels of progesterone are <a href=\"https:\/\/naturalwomanhood.org\/low-progesterone-is-a-big-problem-pms-pmdd-infertility-miscarriage-postpartum-depression-2020\/\" target=\"_blank\" rel=\"noreferrer noopener\">connected<\/a> to premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD), irregular cycles, and infertility.<\/p>\n\n\n\n<p>For women trying to conceive, progesterone is especially important, as it\u2019s necessary for successful implantation and pregnancy. Low progesterone <a href=\"https:\/\/naturalwomanhood.org\/study-suggests-that-giving-progesterone-to-women-may-improve-chances-of-having-a-baby\/\" target=\"_blank\" rel=\"noreferrer noopener\">levels<\/a> later in pregnancy are <a href=\"https:\/\/naturalwomanhood.org\/progesterone-supplementation-helps-prevent-miscarriage-good-news-for-moms-and-babies-2020\/\" target=\"_blank\" rel=\"noreferrer noopener\">linked<\/a> to preterm labor, pregnancy complications, and postpartum depression (PPD).<\/p>\n\n\n\n<p>Even without a diagnosis, women may suspect they have issues with progesterone if they experience pre-period symptoms like breast tenderness, bloating, weight gain, carbohydrate cravings, headaches, fatigue, insomnia, irritability, tearfulness, or depression.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-progesterone-resistance-vs-progesterone-deficiency-nbsp\"><span id=\"progesterone-resistance-vs-progesterone-deficiency\">Progesterone resistance vs. progesterone deficiency&nbsp;<\/span><\/h2>\n\n\n\n<p>It\u2019s well established that low levels of progesterone can cause reproductive health concerns. But is it always a <em>lack <\/em>of progesterone that\u2019s truly causing the problem? Developing research <a href=\"https:\/\/www.factsaboutfertility.org\/endometrial-effects-of-progesterone-a-review\/?mc_cid=aba278ed4a&amp;mc_eid=b9bc2683ab\" target=\"_blank\" rel=\"noreferrer noopener\">suggests <\/a>that these conditions may not be from too low progesterone levels but to a <em>lack of response <\/em>to the progesterone. The ovaries may be making normal amounts but the body isn&#8217;t responding to them normally. <\/p>\n\n\n\n<p>This means it\u2019s possible for a woman to have normal levels of progesterone, yet not receive the full health benefits, because her body is unable to utilize it. It is not only the <em>level<\/em> of progesterone that matters, but the ability of the body\u2019s progesterone receptors to <em>respond<\/em> appropriately. This <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8870180\/\" target=\"_blank\" rel=\"noreferrer noopener\">condition<\/a> is called progesterone resistance [2].&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-is-progesterone-resistance\"><span id=\"what-is-progesterone-resistance\">What is progesterone resistance?<\/span><\/h2>\n\n\n\n<p>In a way that\u2019s similar to <a href=\"https:\/\/naturalwomanhood.org\/insulin-resistance-pcos-fertility-prediabetes\/\">insulin resistance<\/a> (a condition in which the body becomes less and less sensitive to the impact of the hormone insulin on blood sugar regulation), progesterone resistance occurs when progesterone receptors become increasingly unable to respond to progesterone.<\/p>\n\n\n\n<p>Research is still being done to identify precisely why this happens, but it <a href=\"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.13156\" target=\"_blank\" rel=\"noreferrer noopener\">may be connected<\/a> to genetic preconditioning in utero and\/or genetic expression that\u2019s influenced by factors like chronic inflammation [3]. In the second scenario, this resistance is suspected to develop over time [2].<\/p>\n\n\n\n<p>Without adequate effects of progesterone on the reproductive system, women with this resistance may develop additional reproductive concerns, like infertility or miscarriage, endometriosis, adenomyosis, uterine fibroids, polycystic ovary syndrome (PCOS), and endometrial hyperplasia (a precancerous condition) [2].&nbsp;&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-progesterone-resistance-implantation-failure-and-miscarriage\"><span id=\"progesterone-resistance-implantation-failure-and-miscarriage\">Progesterone resistance, implantation failure, and miscarriage<\/span><\/h2>\n\n\n\n<p>Insufficient progesterone is linked to implantation failure and early miscarriages. Without the necessary progesterone to prepare the lining of the uterus or, later, the developing placenta, there will be complications. This is not new information. The role of progesterone resistance, however, is only just beginning to be understood.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-women-respond-differently-to-the-same-levels-of-progesterone\"><span id=\"women-respond-differently-to-the-same-levels-of-progesterone\">Women respond differently to the same levels of progesterone<\/span><\/h2>\n\n\n\n<p>Studies <a href=\"https:\/\/www.factsaboutfertility.org\/endometrial-effects-of-progesterone-a-review\/?mc_cid=aba278ed4a&amp;mc_eid=b9bc2683ab\" target=\"_blank\" rel=\"noreferrer noopener\">show<\/a> that<em> women with the exact same level of progesterone can have different physiological responses<\/em>. This insight <a href=\"https:\/\/www.factsaboutfertility.org\/endometrial-effects-of-progesterone-a-review\/?mc_cid=aba278ed4a&amp;mc_eid=b9bc2683ab\" target=\"_blank\" rel=\"noreferrer noopener\">suggests<\/a> that it is, in fact, \u201ca difference in progesterone response, rather than progesterone levels [that may contribute] to infertility in women with luteal phase defect.\u201d Another study showed women exhibiting normal physiological responses to even low levels of progesterone [4]. Based on this research, it seems likely that it is not only the level of progesterone, but the response to the progesterone present, that contributes to the success of implantation and early pregnancy [4].&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-progesterone-resistance-and-endometriosis\"><span id=\"progesterone-resistance-and-endometriosis\">Progesterone resistance and endometriosis<\/span><\/h2>\n\n\n\n<p>But progesterone resistance may affect more than pregnancy outcomes; it may negatively impact a woman\u2019s ability to conceive at all, such as when it is paired with endometriosis.&nbsp;<\/p>\n\n\n\n<p>Endometriosis is an inflammatory condition where cells like that of the uterine lining (that bleed and shed) are found outside of the uterus. Women with endometriosis often <a href=\"https:\/\/naturalwomanhood.org\/endometriosis-not-just-painful-period-disease\/\" target=\"_blank\" rel=\"noreferrer noopener\">experience<\/a> severe menstrual cramps, pelvic pain, and infertility.&nbsp;<\/p>\n\n\n\n<p>Progesterone is anti-inflammatory in nature, and has the benefit of suppressing these cells and preventing unchecked estrogen activity (which further inflames endometriosis symptoms). Women with endometriosis who suffer from progesterone resistance don\u2019t have this natural suppressant. The cells are more likely to become inflamed and spread, increasing the level and degree of endometriosis [3][5].<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-do-you-treat-progesterone-resistance\"><span id=\"how-do-you-treat-progesterone-resistance\">How do you treat progesterone resistance?<\/span><\/h2>\n\n\n\n<p>Understanding the role progesterone resistance plays in these reproductive conditions is critical for progress in diagnosis and treatment. At present, research on progesterone resistance is still in the very early stages. Continued research is needed on both causes and how to treat it. Once the causes are understood, treatment options can hopefully be developed to reduce the effect of progesterone resistance especially on infertility, miscarriage, endometriosis and more.&nbsp;&nbsp;<\/p>\n\n\n\n<p>References:<\/p>\n\n\n\n[1] DeMayo FJ, Lydon JP. 90 YEARS OF PROGESTERONE: New insights into progesterone receptor signaling in the endometrium required for embryo implantation. J Mol Endocrinol. 2020 Jul;65(1):T1-T14. doi: 10.1530\/JME-19-0212. PMID: 31809260; PMCID: PMC7261627<\/p>\n\n\n\n[2] MacLean JA 2nd, Hayashi K. Progesterone Actions and Resistance in Gynecological Disorders. Cells. 2022 Feb 13;11(4):647. doi: 10.3390\/cells11040647. PMID: 35203298; PMCID: PMC8870180.<\/p>\n\n\n\n[3] Patel, Bansari G et al. \u201cProgesterone resistance in endometriosis: origins, consequences and interventions.\u201d <em>Acta obstetricia et gynecologica Scandinavica<\/em> vol. 96,6 (2017): 623-632. doi:10.1111\/aogs.13156<\/p>\n\n\n\n[4]&nbsp; Young, Steven L, and Bruce A Lessey. \u201cProgesterone function in human endometrium: clinical perspectives.\u201d <em>Seminars in reproductive medicine<\/em> vol. 28,1 (2010): 5-16. doi:10.1055\/s-0029-1242988[5] Aghajanova, Lusine et al. \u201cAltered gene expression profiling in endometrium: evidence for progesterone resistance.\u201d <em>Seminars in reproductive medicine<\/em> vol. 28,1 (2010): 51-8. doi:10.1055\/s-0029-1242994<\/p>\n","protected":false},"excerpt":{"rendered":"Y el papel que puede desempe\u00f1ar en el aborto espont\u00e1neo y la endometriosis","protected":false},"author":109,"featured_media":20518,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","csco_singular_sidebar":"","csco_page_header_type":"","csco_page_load_nextpost":"","csco_post_video_location":[],"csco_post_video_url":"","csco_post_video_bg_start_time":0,"csco_post_video_bg_end_time":0,"footnotes":""},"categories":[5362,5364,5366,5509,5181],"tags":[4719,6179,5320],"class_list":{"0":"post-20517","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cycle-dysfunctions","8":"category-endometriosis","9":"category-hormone-imbalance","10":"category-pregnancy-loss","11":"category-reproductive-and-menstrual-disorders","12":"tag-endometriosis","13":"tag-low-progesterone","14":"tag-miscarriage","15":"cs-entry","16":"cs-video-wrap"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>What is progesterone resistance? - Natural Womanhood<\/title>\n<meta name=\"description\" content=\"You&#039;ve heard of insulin resistance, but what is progesterone resistance? 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